For Christians, the Holy Scriptures of the Old and New Testaments are the foundational text of our faith, both the ultimate source of illumination in our relationship with God and the ultimate tether in our speculation about God and God’s ways. The practice of using one or more particular interpretive methodologies when reading Scripture is known as hermeneutics. In unworthy homage to David Letterman, now recently departed from the late-night television scene, I offer these ten hermeneutical principles, certainly more by way of a discussion starter than a discussion ender.